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Sugi Predict / Compounds / SCHEMBL4610260

SCHEMBL4610260

SCHEMBL4610260

COc1cc2c(Oc3c(F)cccc3NC(=O)C(=O)NCCc3ccccc3)ccnc2cc1OCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 12/20 0.55
▸ KDR P35968 7/20 0.50
▸ PDGFRA P16234 5/20 0.50
▸ POLB P06746 1/20 0.46
▸ AXL P30530 2/20 0.45
▸ HDAC1 Q13547 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19689586 0.85 MET (0.47) METKDRPDGFRA
SCHEMBL371811 0.85 MET (0.64) METKDRPOLBAXL
SCHEMBL29693647 0.84 MET (0.49) METKDRPDGFRAAXL
SCHEMBL372095 0.80 MET (0.68) METKDRPOLB
SCHEMBL2329031 0.78 KDR (0.52) METKDRPDGFRAHDAC1
SCHEMBL15062477 0.77 MET (0.58) METKDRPDGFRAAXL
SCHEMBL9987209 0.77 MET (0.62) METKDRPDGFRAAXL
SCHEMBL5223147 0.76 MET (0.58) METKDRAXL
SCHEMBL15266665 0.76 MET (0.62) METKDRPOLB
SCHEMBL20216678 0.75 MET (0.61) METKDRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1673085-A4 C-MET MODULATORS AND METHODS OF USE EXELIXIS INC (US) 2008-12-10 — — EP disclosed
EP-1673085-A2 C-MET MODULATORS AND METHODS OF USE Exelixis, Inc. (US) 2006-06-28 — — EP disclosed
WO-2005030140-A2 C-MET MODULATORS AND METHODS OF USE EXELIXIS, INC. (US) 2005-04-07 — — WO disclosed