Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2327778 | 0.85 | SMN1; SMN2 (0.39) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2331276 | 0.84 | POLB (0.41) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2324582 | 0.84 | IKBKB (0.39) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2327152 | 0.84 | IKBKB (0.37) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2331737 | 0.83 | IKBKB (0.38) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2332736 | 0.83 | IKBKB (0.38) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2334798 | 0.83 | PTGER1 (0.39) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2323238 | 0.83 | IKBKB (0.40) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2331384 | 0.81 | IKBKB (0.38) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2330919 | 0.81 | IKBKB (0.38) | IKBKBKDM4EPPARGNCOA2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |