Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 8/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | OGA | O60502 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324582 | 0.86 | IKBKB (0.39) | IKBKBPPARGKDM4EHSD17B10NCOA2 | |
| SCHEMBL2324724 | 0.85 | IKBKB (0.37) | IKBKBPPARGKDM4EHSD17B10NCOA2 | |
| SCHEMBL2332736 | 0.85 | IKBKB (0.38) | IKBKBPPARGKDM4EHSD17B10NCOA2 | |
| SCHEMBL2333861 | 0.83 | IKBKB (0.38) | IKBKBPPARGKDM4EHSD17B10NCOA2 | |
| SCHEMBL2330217 | 0.83 | IKBKB (0.38) | IKBKBPPARGKDM4EHSD17B10NCOA2 | |
| SCHEMBL2334798 | 0.81 | PTGER1 (0.39) | IKBKBPPARGKDM4EHSD17B10NCOA2 | |
| SCHEMBL2323238 | 0.81 | IKBKB (0.40) | IKBKBPPARGKDM4EHSD17B10NCOA2 | |
| SCHEMBL2330919 | 0.81 | IKBKB (0.38) | IKBKBPPARGKDM4EHSD17B10NCOA2 | |
| SCHEMBL2331276 | 0.81 | POLB (0.41) | IKBKBPPARGKDM4EHSD17B10NCOA2 | |
| SCHEMBL2327745 | 0.80 | IKBKB (0.39) | IKBKBPPARGKDM4EHSD17B10NCOA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |