Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2271571 | 0.94 | ALOX15 (0.63) | ALOX15ALDH1A1GAAKDM4ELMNA | |
| SCHEMBL2270748 | 0.90 | ALOX15 (0.50) | ALOX15ALDH1A1GAAKDM4ELMNA | |
| SCHEMBL6741629 | 0.87 | ALOX15 (0.55) | ALOX15ALDH1A1GAAKDM4EGLA | |
| SCHEMBL2270984 | 0.82 | KDM4E (0.51) | ALDH1A1GAAKDM4ELMNAGLA | |
| SCHEMBL12370192 | 0.81 | TLR8 (0.44) | ALOX15ALDH1A1F2F10MAOB | |
| SCHEMBL5225410 | 0.81 | CA12 (0.47) | ALOX15F2F10TLR8CA12 | |
| SCHEMBL2333763 | 0.80 | CYP19A1 (0.47) | ALOX15F2F10MAOATLR8 | |
| SCHEMBL284155 | 0.80 | TLR8 (0.50) | ALOX15FLT3F2F10MAOA | |
| SCHEMBL2331524 | 0.80 | KMT2A (0.55) | ALOX15ALDH1A1KDM4EF2F10 | |
| SCHEMBL2327940 | 0.80 | TLR8 (0.43) | ALOX15F2F10TLR8CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130046103-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | MAPI PHARMA LIMITED (IL) | 2013-02-21 | — | — | US | disclosed |
| EP-2533636-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | Mapi Pharma Limited (IL) | 2012-12-19 | — | — | EP | disclosed |
| CN-102753018-A | Preparation of benzofurans and their use as synthetic intermediates | MAPI PHARMA HOLDINGS CYPRUS LTD | 2012-10-24 | — | — | CN | disclosed |
| WO-2012062918-A1 | PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES | LEK PHARMACEUTICALS D.D. (SI) | 2012-05-18 | — | — | WO | disclosed |
| WO-2011099010-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | MAPI PHARMA HOLDINGS (CYPRUS) LIMITED (CY) | 2011-08-18 | — | — | WO | disclosed |
| US-20100275388-A1 | COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES | L'OREAL S.A. (FR) | 2010-11-04 | — | — | US | disclosed |
| US-20040086983-A1 | Method for producing a heterocyclic compound and an aromatic carboxylic acid having one or more hydroxyl groups, and modified aromatic ring dioxygenase | MARINE BIOTHECHNOLOGY INSTITUTE., LTD. (JP) | 2004-05-06 | — | — | US | disclosed |
| CN-1054128-C | 4-alkoxy-2,6-ditert-butyphynol derivative | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2000-07-05 | — | — | CN | disclosed |
| CN-1112115-A | 4-alkoxy-2, 6-di-tert-butylphenol derivative | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1995-11-22 | — | — | CN | disclosed |
| US-4966907-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | MERCK & CO., INC. (US) | 1990-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130046103-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | CYP2F1, CYP4F3, CYP2D6 | ALOX15 2926/4885ALDH1A1 1830/4885GAA 2136/4885 |
| US-20100275388-A1 | COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES | KRT18, KRTCAP2, FASN | ALOX15 229/4885ALDH1A1 1792/4885GAA 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.