Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10139429 | 0.89 | MAOB (0.46) | TLR8MAOBALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL11559549 | 0.82 | MAOB (0.49) | MAOBALDH1A1TAS1R3TAS1R1ADORA3 | |
| SCHEMBL2331524 | 0.81 | KMT2A (0.55) | TLR8MAOBALDH1A1ALOX15F2 | |
| SCHEMBL2327940 | 0.81 | TLR8 (0.43) | TLR8ALOX15F2F10MAPT | |
| SCHEMBL2333763 | 0.81 | CYP19A1 (0.47) | TLR8ALOX15F2F10MAPT | |
| SCHEMBL284155 | 0.81 | TLR8 (0.50) | TLR8ALOX15F2F10MAPT | |
| SCHEMBL2326095 | 0.81 | TLR8 (0.43) | TLR8ALOX15F2F10MAPT | |
| SCHEMBL2330441 | 0.81 | ALOX15 (0.58) | TLR8MAOBALDH1A1ALOX15F2 | |
| SCHEMBL10729516 | 0.81 | F2 (0.46) | MAOBALDH1A1TAS1R3TAS1R1F2 | |
| Hydrochloric Acid SCHEMBL5395881 | 0.80 | TLR8 (0.52) | TLR8ALOX15F2F10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3039016-B1 | PROCESS FOR PREPARING DRONEDARONE AND SALTS THEREOF | GILEAD SCIENCES INC (US) | 2017-08-02 | — | — | EP | disclosed |
| US-9708281-B2 | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent | SANOFI (FR) | 2017-07-18 | — | — | US | disclosed |
| US-9701654-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2017-07-11 | — | — | US | disclosed |
| US-9611242-B2 | Process for preparation of dronedarone by N-butylation | SANOFI (FR) | 2017-04-04 | — | — | US | disclosed |
| US-9512097-B2 | Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives | LEK PHARMACEUTICALS D.D. (SI) | 2016-12-06 | — | — | US | disclosed |
| US-20160272606-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | SANOFI (FR) | 2016-09-22 | — | — | US | disclosed |
| US-9382223-B2 | Process for preparation of dronedarone by oxidation of a hydroxyl group | SANOFI (FR) | 2016-07-05 | — | — | US | disclosed |
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2016-03-17 | — | — | US | disclosed |
| US-20160075673-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT | SANOFI (FR) | 2016-03-17 | — | — | US | disclosed |
| US-9249119-B2 | Process for the preparation of dronedarone by oxidation of a sulphenyl group | SANOFI (FR) | 2016-02-02 | — | — | US | disclosed |
| US-20140114081-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | SANOFI (FR) | 2014-04-24 | — | — | US | disclosed |
| US-20140081035-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY MESYLATION | SANOFI (FR) | 2014-03-20 | — | — | US | disclosed |
| US-20140018554-A1 | REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND | SANOFI (FR) | 2014-01-16 | — | — | US | disclosed |
| US-8481763-B2 | Preparation process of dronedarone and its salts | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-07-09 | — | — | US | disclosed |
| US-20130072697-A1 | PREPARATION PROCESS OF DRONEDARONE AND ITS SALTS | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-03-21 | — | — | US | disclosed |
| US-20130046103-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | MAPI PHARMA LIMITED (IL) | 2013-02-21 | — | — | US | disclosed |
| WO-2011099010-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | MAPI PHARMA HOLDINGS (CYPRUS) LIMITED (CY) | 2011-08-18 | — | — | WO | disclosed |
| US-7989472-B2 | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20090209564-A1 | Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds And Methods Of Use | MERCK & CO., INC. | 2009-08-20 | — | — | US | disclosed |
| US-7312345-B2 | Process for the preparation of dronedarone | ISP INVESTMENTS INC. (US) | 2007-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140114081-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | CYP3A43, CYP3A4, CYP2D6 | TLR8 4809/4885MAOB 642/4885ALDH1A1 746/4885 |
| US-20130072697-A1 | PREPARATION PROCESS OF DRONEDARONE AND ITS SALTS | CYP2D6, CYP3A4, CYP2C9 | TLR8 4463/4885MAOB 2467/4885ALDH1A1 1423/4885 |
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, CYP3A43, CYP7A1 | TLR8 4711/4885MAOB 438/4885ALDH1A1 352/4885 |
| US-20090209564-A1 | Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds And Methods Of Use | GCGR, GLP1R, GPR119 | TLR8 1944/4885MAOB 1677/4885ALDH1A1 4625/4885 |
| US-20130046103-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | CYP2F1, CYP4F3, CYP2D6 | TLR8 4622/4885MAOB 791/4885ALDH1A1 1830/4885 |
| US-20160075673-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT | DHCR7, CYP3A43, CYP7A1 | TLR8 4778/4885MAOB 706/4885ALDH1A1 415/4885 |
| US-20160272606-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | CYP2D6, CYP2B6, POR | TLR8 4680/4885MAOB 264/4885ALDH1A1 259/4885 |
| US-20140018554-A1 | REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND | CYP2D6, CYP2B6, CYP11B2 | TLR8 4065/4885MAOB 256/4885ALDH1A1 89/4885 |
| US-20140081035-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY MESYLATION | CYP2B6, CYP2D6, CYP7A1 | TLR8 4689/4885MAOB 244/4885ALDH1A1 407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.