Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | PRF1 | P14222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7007714 | 0.98 | PARP1 (0.47) | PARP1TSHRKDM1ALCKKDM4E | |
| SCHEMBL2115451 | 0.87 | PARP1 (0.44) | PARP1TSHRKDM1ALCKKDM4E | |
| SCHEMBL5239085 | 0.85 | PARP1 (0.50) | PARP1TSHRKDM1AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7003754 | 0.81 | PARP1 (0.44) | PARP1KDM4EALDH1A1 | |
| SCHEMBL30924717 | 0.81 | HDAC6 (0.42) | PARP1KDM4E | |
| SCHEMBL7009677 | 0.75 | NPC1 (0.50) | PARP1ALDH1A1 | |
| SCHEMBL7094259 | 0.74 | PARP1 (0.39) | PARP1 | |
| SCHEMBL784887 | 0.74 | KDM1A (0.41) | PARP1TSHRKDM1ALCKKDM4E | |
| SCHEMBL16229535 | 0.73 | PARP1 (0.52) | PARP1KDM4EALDH1A1TDP2 | |
| SCHEMBL23387607 | 0.73 | PARP1 (0.52) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086879-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |