Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 6/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8198906 | 0.88 | HSD17B3 (0.40) | KDM1ATSHRLCKALDH1A1HSD17B10 | |
| SCHEMBL484995 | 0.83 | ALDH1A1 (0.48) | KDM1ATSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL30809642 | 0.83 | ALDH1A1 (0.48) | KDM1ATSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL5672576 | 0.82 | KDM1A (0.45) | KDM1ATSHRLCKALDH1A1HSD17B10 | |
| SCHEMBL23100767 | 0.81 | RAB9A (0.52) | ALDH1A1KDM4EKMT2AMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27838744 | 0.81 | ALDH1A1 (0.47) | KDM1ATSHRALDH1A1HSD17B10KDM4E | |
| SCHEMBL1478300 | 0.77 | TRPA1 (0.33) | ALDH1A1 | |
| SCHEMBL876227 | 0.77 | PTPRC (0.49) | TSHRLCKALDH1A1HSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL27902605 | 0.76 | PTPRC (0.48) | TSHRLCKALDH1A1HSD17B10KDM4E | |
| SCHEMBL1478314 | 0.76 | CYP2D6 (0.32) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107205972-A | Substituted N- (2- (amino) -2-oxoethyl) benzamide inhibitors of autotaxin and their preparation and use in the treatment of LPA-dependent or LPA-mediated diseases | X-RX股份有限公司 | 2017-09-26 | — | — | CN | claimed |
| US-20230149414-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-18 | — | — | US | disclosed |
| CN-107205972-A | Substituted N- (2- (amino) -2-oxoethyl) benzamide inhibitors of autotaxin and their preparation and use in the treatment of LPA-dependent or LPA-mediated diseases | X-RX股份有限公司 | 2017-09-26 | — | — | CN | disclosed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| WO-2008114123-A1 | SPIRO BENZIMIDAZOLE DERIVATIVES AS ACID PUMP INHIBITORS | RAQUALIA PHARMA INC. (JP) | 2008-09-25 | — | — | WO | disclosed |
| EP-0923542-B1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | UPJOHN CO (US) | 2003-08-20 | — | — | EP | disclosed |
| EP-0968168-A1 | AROMATIC TETRACYCLIC COMPOUNDS OF THE RETINOID TYPE, METHOD FOR PREPARING AND USE | Centre Europeen de Bioprospective -CEB (FR) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998031654-A1 | AROMATIC TETRACYCLIC COMPOUNDS OF THE RETINOID TYPE, METHOD FOR PREPARING AND USE | CENTRE EUROPEEN DE BIOPROSPECTIVE -CEB- (FR) | 1998-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230149414-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | KDM1A 2149/4885TSHR 4351/4885LCK 4633/4885 |
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | KDM1A 1493/4885TSHR 586/4885LCK 2969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.