Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2330705 | 1.00 | KCNH2 (0.37) | KCNH2 | |
| SCHEMBL2325713 | 0.85 | KCNH2 (0.46) | KCNH2 | |
| SCHEMBL2325719 | 0.85 | KCNH2 (0.46) | KCNH2 | |
| SCHEMBL2328590 | 0.85 | MTNR1A (0.42) | KCNH2 | |
| SCHEMBL2325491 | 0.85 | MTNR1A (0.42) | KCNH2 | |
| SCHEMBL3120032 | 0.76 | PTGS2 (0.36) | KCNH2 | |
| SCHEMBL2325644 | 0.76 | PTGS2 (0.36) | KCNH2 | |
| SCHEMBL2325639 | 0.76 | PTGS2 (0.36) | KCNH2 | |
| SCHEMBL2543204 | 0.76 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL2537544 | 0.76 | KCNH2 (0.45) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167494-B1 | 3-AMINO-6-(1-AMINO-ETHYL)-TETRAHYDROPYRAN DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |
| EP-2167494-A1 | 3-AMINO-6-(1-AMINO-ETHYL)-TETRAHYDROPYRAN DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008152603-A1 | 3-AMINO-6-(1-AMINO-ETHYL)-TETRAHYDROPYRAN DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-12-18 | — | — | WO | disclosed |