Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2328930 | 0.91 | HCRTR1 (0.44) | IKBKBRXRARXRBRXRGNR4A2 | |
| SCHEMBL2323238 | 0.90 | IKBKB (0.40) | IKBKBNR4A2HCRTR1HCRTR2KDM4E | |
| SCHEMBL2332690 | 0.90 | NR4A1 (0.37) | IKBKBNR4A2HCRTR1HCRTR2SLC9A1 | |
| SCHEMBL2327523 | 0.90 | IKBKB (0.41) | IKBKBRXRARXRBRXRGMEN1 | |
| SCHEMBL2327731 | 0.88 | RXRA (0.41) | IKBKBRXRARXRBRXRGMEN1 | |
| SCHEMBL2327570 | 0.88 | LRRK2 (0.36) | IKBKBHCRTR1HCRTR2KDM4EALDH1A1 | |
| SCHEMBL2327049 | 0.88 | IKBKB (0.48) | IKBKBRXRARXRBKMT2ASLC9A1 | |
| SCHEMBL2328920 | 0.88 | IKBKB (0.35) | IKBKBKMT2AHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL1704456 | 0.87 | IKBKB (0.41) | IKBKBRXRARXRBRXRGNR4A2 | |
| SCHEMBL2328104 | 0.86 | HCRTR1 (0.36) | IKBKBRXRARXRBKMT2AHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |