Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2328930 | 0.91 | HCRTR1 (0.44) | NR4A2HCRTR1HCRTR2SLC9A1ADORA2A | |
| SCHEMBL2323238 | 0.90 | IKBKB (0.40) | NR4A2HCRTR1HCRTR2ADORA2AIKBKB | |
| SCHEMBL2327731 | 0.90 | RXRA (0.41) | SLC9A1IKBKBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2331266 | 0.90 | IKBKB (0.45) | NR4A2HCRTR1HCRTR2PDE4BSLC9A1 | |
| SCHEMBL2329098 | 0.90 | MAPK14 (0.34) | IKBKBKDM4EHSD17B10 | |
| SCHEMBL2327570 | 0.88 | LRRK2 (0.36) | HCRTR1HCRTR2TRPM8ADORA2AIKBKB | |
| SCHEMBL2327049 | 0.88 | IKBKB (0.48) | SLC9A1MAOBADORA2AIKBKBKDM4E | |
| SCHEMBL2327644 | 0.88 | ADORA2A (0.39) | HCRTR1HCRTR2ADORA2AIKBKB | |
| SCHEMBL2328920 | 0.88 | IKBKB (0.35) | HCRTR1HCRTR2ADORA2AIKBKBTP53 | |
| SCHEMBL1704477 | 0.87 | FPR2 (0.35) | NR4A1NR4A2NR4A3SLC9A1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |