SCHEMBL23313227

SCHEMBL23313227

CNc1ccc2ccc(OC[C@H]3O[C@@H](n4cc(CC5CCCC5)c5c(N)ncnc54)[C@H](C)[C@@H]3O)cc2n1

nearest known ligand 0.90

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 17/20 0.90
▸ METTL3 Q86U44 14/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25016858 0.95 PRMT5 (1.00) PRMT5METTL3
SCHEMBL23313255 0.92 PRMT5 (1.00) PRMT5METTL3
SCHEMBL23313198 0.90 PRMT5 (1.00) PRMT5METTL3
SCHEMBL29772289 0.83 METTL3 (0.98) PRMT5METTL3
SCHEMBL25015662 0.83 METTL3 (0.98) PRMT5METTL3
SCHEMBL23273845 0.83 METTL3 (0.98) PRMT5METTL3
SCHEMBL23313940 0.83 METTL3 (1.00) PRMT5METTL3
SCHEMBL23313157 0.82 PRMT5 (0.78) PRMT5METTL3
SCHEMBL23313197 0.81 PRMT5 (1.00) PRMT5METTL3
SCHEMBL25015669 0.81 PRMT5 (1.00) PRMT5METTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021079196-A9 METTL3 MODULATORS ACCENT THERAPEUTICS, INC (US) 2022-07-14 — — WO disclosed
WO-2021079196-A2 METTL3 MODULATORS ACCENT THERAPEUTICS, INC (US) 2021-04-29 — — WO disclosed
Send feedback