Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.31 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81650 | 0.68 | NISCH (0.59) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL351341 | 0.68 | ADRA2A (0.39) | NISCHADRA2AADRA1ASMN1; SMN2ADRA2B | |
| SCHEMBL16427491 | 0.68 | NISCH (0.37) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL15843275 | 0.67 | SMN1; SMN2 (0.35) | SMN1; SMN2KCNH2HRH3 | |
| SCHEMBL1461133 | 0.67 | NISCH (0.39) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL31001159 | 0.66 | ADRA2A (0.37) | NISCHADRA2AADRA1ASMN1; SMN2ADRA2B | |
| SCHEMBL28425230 | 0.66 | NISCH (0.56) | NISCHMTORADKALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL1536214 | 0.66 | NISCH (0.56) | NISCHMTORADKALDH1A1MEN1 | |
| Methane SCHEMBL27599015 | 0.66 | ADRA2A (0.37) | NISCHADRA2AADRA1ASMN1; SMN2ADRA2B | |
| SCHEMBL14892763 | 0.65 | MMP13 (0.36) | MEN1KMT2AADRA1ASMN1; SMN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514791-A | Heterocycloimidazole-2-oxazoline compound and preparation method and application thereof | 贵州大学 | 2023-08-01 | — | — | CN | claimed |
| CN-115073454-B | Imidazo pyridine-2-oxazoline compound and preparation method and application thereof | 贵州大学 | 2024-03-08 | — | — | CN | disclosed |
| CN-116514791-A | Heterocycloimidazole-2-oxazoline compound and preparation method and application thereof | 贵州大学 | 2023-08-01 | — | — | CN | disclosed |
| CN-116514791-A | Heterocycloimidazole-2-oxazoline compound and preparation method and application thereof | 贵州大学 | 2023-08-01 | — | — | CN | disclosed |
| EP-2121621-B1 | LXR AND FXR MODULATORS | EXELIXIS PATENT CO LLC (US) | 2014-05-07 | — | — | EP | disclosed |
| US-7998995-B2 | LXR and FXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100069367-A1 | LXR and FXR Modulators | EXELIXIS, INC. (US) | 2010-03-18 | — | — | US | disclosed |
| EP-2121621-A1 | LXR AND FXR MODULATORS | Exelixis, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008073825-A1 | LXR AND FXR MODULATORS | EXELIXIS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069367-A1 | LXR and FXR Modulators | NR1H3, NR1H2, NR1H4 | NISCH 4222/4885MTOR 3488/4885ADK 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.