Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.61 |
| ▸ | FAP | Q12884 | 2/20 | 0.61 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 8/20 | 0.42 |
| ▸ | REN | P00797 | 4/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PEPD | P12955 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17282610 | 0.95 | PREP (0.56) | PREPFAPDPP4DPP8DPP9 | |
| SCHEMBL17282580 | 0.91 | PREP (0.52) | PREPFAPDPP4DPP8DPP9 | |
| SCHEMBL26616440 | 0.88 | PREP (0.47) | PREPFAPACERENACE2 | |
| SCHEMBL26616435 | 0.88 | PREP (0.47) | PREPFAPACERENACE2 | |
| SCHEMBL26616445 | 0.88 | PREP (0.47) | PREPFAPACERENACE2 | |
| SCHEMBL17282584 | 0.88 | PREP (0.64) | PREPFAPDPP4DPP8DPP9 | |
| SCHEMBL17117574 | 0.87 | PREP (0.46) | PREPFAPDPP4ACEREN | |
| SCHEMBL11376437 | 0.86 | PREP (0.62) | PREPFAPACERENACE2 | |
| SCHEMBL11376449 | 0.86 | PREP (0.62) | PREPFAPACERENACE2 | |
| SCHEMBL13402537 | 0.85 | FAP (0.45) | PREPFAPDPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145944-B1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2021-05-05 | — | — | EP | disclosed |