Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.40 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15413220 | 0.87 | FGFR4 (0.63) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL23314894 | 0.83 | FGFR4 (0.54) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL18131697 | 0.80 | FGFR4 (0.40) | FGFR4MAPK1FGFR1FGFR2FGFR3 | |
| SCHEMBL18131690 | 0.77 | FGFR4 (0.50) | FGFR4MAPK1FGFR1FGFR2FGFR3 | |
| SCHEMBL15434003 | 0.73 | FGFR4 (0.65) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL18131708 | 0.73 | MAPT (0.39) | FGFR4MAPK1FGFR1ALDH1A1MEN1 | |
| SCHEMBL18131808 | 0.72 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL21756608 | 0.71 | FGFR4 (0.39) | FGFR4MAPK1FGFR1FGFR2FGFR3 | |
| SCHEMBL15413168 | 0.69 | FGFR4 (0.60) | FGFR4MAPK1FGFR1RPS6KB2ALDH1A1 | |
| SCHEMBL21386604 | 0.69 | FGFR4 (0.37) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872491-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2021-05-05 | — | — | EP | disclosed |