Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15412984 | 0.94 | HTT (0.49) | HTTDHFRALDH1A1KDM4EFGFR4 | |
| SCHEMBL29545589 | 0.94 | HTT (0.49) | HTTDHFRALDH1A1KDM4EFGFR4 | |
| SCHEMBL6736863 | 0.86 | HTT (0.51) | HTTDHFRALDH1A1KDM4EFGFR4 | |
| SCHEMBL16071413 | 0.80 | HTT (0.45) | HTTDHFRFGFR4 | |
| SCHEMBL3970774 | 0.79 | DHFR (0.55) | HTTDHFRMAPTLMNATSHR | |
| SCHEMBL20733981 | 0.75 | HTT (0.48) | HTTDHFR | |
| SCHEMBL6736865 | 0.75 | DHFR (0.46) | HTTDHFRFGFR4 | |
| SCHEMBL6623077 | 0.74 | LMNA (0.46) | HTTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL28734481 | 0.74 | NPC1 (0.43) | HTTALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL29546388 | 0.74 | NPC1 (0.43) | HTTALDH1A1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872491-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2021-05-05 | — | — | EP | disclosed |