Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.47 |
| ▸ | PARP1 | P09874 | 4/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29800672 | 1.00 | TNKS (0.47) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL23316383 | 0.93 | TNKS (0.48) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL29800566 | 0.93 | TNKS (0.48) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL23293921 | 0.84 | ALDH1A1 (0.61) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL23293816 | 0.80 | TNKS (0.61) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL4373847 | 0.77 | IP6K1 (0.48) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL23316396 | 0.77 | TNKS (0.44) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL25151006 | 0.74 | TNKS (0.44) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL25152231 | 0.73 | TNKS (0.52) | TNKSPARP1TNKS2KDM4EALDH1A1 | |
| SCHEMBL4365201 | 0.73 | ALDH1A1 (0.46) | TNKSPARP1TNKS2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220287748-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR SPINAL MUSCULAR ATROPHY | REBORNA BIOSCIENCES, INC. (JP) | 2022-09-15 | — | — | US | disclosed |
| EP-3816160-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR SPINAL MUSCULAR ATROPHY | Reborna Biosciences, Inc. (JP) | 2021-05-05 | — | — | EP | disclosed |