Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 6/20 | 0.46 |
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23542180 | 0.93 | NPC1 (0.52) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL23542216 | 0.91 | MAOB (0.49) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL23542217 | 0.89 | HPGD (0.47) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL20473377 | 0.89 | NPC1 (0.58) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL23542244 | 0.89 | NPC1 (0.58) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL23542220 | 0.89 | NPC1 (0.58) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL23542265 | 0.87 | HPGD (0.45) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL23316795 | 0.86 | NPC1 (0.52) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL22625188 | 0.85 | NPC1 (0.60) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL23542261 | 0.84 | MAOB (0.47) | NPC1RAB9AKDM4EGLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040990-B2 | Compounds containing Si atoms for optically active devices | MERCK PATENT GMBH (DE) | 2021-06-22 | — | — | US | disclosed |
| EP-3583100-B1 | COMPOUNDS CONTAINING SI ATOMS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2021-05-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040990-B2 | Compounds containing Si atoms for optically active devices | UACA, EYA3, PDE6C | NPC1 2054/4885RAB9A 1064/4885KDM4E 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.