Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 19/20 | 0.67 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.67 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.67 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.67 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.67 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.67 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.67 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.67 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.67 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.67 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.67 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.67 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.67 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.67 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.67 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.67 |
| ▸ | PSMA6 | P60900 | 3/20 | 0.67 |
| ▸ | PSMA8 | Q8TAA3 | 3/20 | 0.67 |
| ▸ | PSMB7 | Q99436 | 3/20 | 0.67 |
| ▸ | PSMD11 | O00231 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20972368 | 1.00 | PSMB5 (0.67) | PSMB5PSMB1PSMB11PSMA7PSMA1 | |
| SCHEMBL13416356 | 1.00 | PSMB5 (0.67) | PSMB5PSMB1PSMB11PSMA7PSMA1 | |
| SCHEMBL20779065 | 1.00 | PSMB5 (0.67) | PSMB5PSMB1PSMB11PSMA7PSMA1 | |
| SCHEMBL22113435 | 0.89 | PSMB5 (0.68) | PSMB5PSMB1PSMB11PSMA7PSMA1 | |
| SCHEMBL8260325 | 0.89 | PSMB5 (0.68) | PSMB5PSMB1PSMB11PSMA7PSMA1 | |
| SCHEMBL607126 | 0.89 | PSMB5 (0.68) | PSMB5PSMB1PSMB11PSMA7PSMA1 | |
| SCHEMBL14043421 | 0.89 | PSMB5 (0.64) | PSMB5PSMB1PSMB11PSMA7PSMA1 | |
| SCHEMBL13451115 | 0.89 | PSMB5 (0.64) | PSMB5PSMB1PSMB11PSMA7PSMA1 | |
| Hydrochloric Acid SCHEMBL3746894 | 0.88 | PSMB5 (0.61) | PSMB5PSMB1PSMB11PSMA7PSMA1 | |
| Hydrochloric Acid SCHEMBL4339493 | 0.88 | PSMB5 (0.61) | PSMB5PSMB1PSMB11PSMA7PSMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083922-A1 | Proteasome Inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-03-14 | — | — | US | disclosed |
| US-20230265110-A1 | Proteasome Inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-08-24 | — | — | US | disclosed |
| US-20220251117-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2022-08-11 | — | — | US | disclosed |
| US-20220017542-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2022-01-20 | — | — | US | disclosed |
| US-20210206784-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2021-07-08 | — | — | US | disclosed |
| US-20200407376-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2020-12-31 | — | — | US | disclosed |
| US-20200199159-A1 | PROCESS FOR MAKING IXAZOMIB OR INTERMEDIATES THEREFOR | SYNTHON B.V. (NL) | 2020-06-25 | — | — | US | disclosed |
| US-20200190118-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2020-06-18 | — | — | US | disclosed |
| US-20190144470-A1 | PROTEASOME INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-05-16 | — | — | US | disclosed |
| US-20180305380-A1 | PROTEASOME INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-25 | — | — | US | disclosed |
| US-7687662-B2 | e.g. 1-({[(2,3-difluorobenzoyl)amino]acetyl}amino)-3-methylbutyl]boronic acid; anticarcinogenic, antiproliferative agent | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687662-B2 | e.g. 1-({[(2,3-difluorobenzoyl)amino]acetyl}amino)-3-methylbutyl]boronic acid; anticarcinogenic, antiproliferative agent | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-20090291918-A1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090291918-A1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-7576206-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576206-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-20090042836-A1 | e.g. 1-({[(2,3-difluorobenzoyl)amino]acetyl}amino)-3-methylbutyl]boronic acid; anticarcinogenic, antiproliferative agent | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-02-12 | — | — | US | disclosed |
| US-20090042836-A1 | e.g. 1-({[(2,3-difluorobenzoyl)amino]acetyl}amino)-3-methylbutyl]boronic acid; anticarcinogenic, antiproliferative agent | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-02-12 | — | — | US | disclosed |
| US-7442830-B1 | Proteasome inhibitors | MILLENIUM PHARMACEUTICALS, INC. (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442830-B1 | Proteasome inhibitors | MILLENIUM PHARMACEUTICALS, INC. (US) | 2008-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291918-A1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | PSMB11, PSMB5, PSMB6 | PSMB5 2/4885PSMB1 4/4885PSMB11 1/4885 |
| US-20180305380-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
| US-20240083922-A1 | Proteasome Inhibitors | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
| US-20220251117-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
| US-20190144470-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
| US-20210206784-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
| US-20220017542-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
| US-20230265110-A1 | Proteasome Inhibitors | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
| US-20200407376-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
| US-20090042836-A1 | e.g. 1-({[(2,3-difluorobenzoyl)amino]acetyl}amino)-3-methylbutyl]boronic acid; anticarcinogenic, antiproliferative agent | PSMB1, PSMB11, PSMB5 | PSMB5 3/4885PSMB1 1/4885PSMB11 2/4885 |
| US-20200199159-A1 | PROCESS FOR MAKING IXAZOMIB OR INTERMEDIATES THEREFOR | GLP1R, CDK11B, GIPR | PSMB5 2949/4885PSMB1 1496/4885PSMB11 216/4885 |
| US-20200190118-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.