Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | FABP3 | P05413 | 3/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28880248 | 0.82 | FABP3 (0.46) | ALDH1A1GAASMN1; SMN2FABP3HPGD | |
| SCHEMBL27796494 | 0.81 | PTGS2 (0.39) | ALDH1A1SMN1; SMN2FABP3HPGDHTT | |
| SCHEMBL27977719 | 0.78 | SMN1; SMN2 (0.36) | ALDH1A1SMN1; SMN2FABP3HPGDHTT | |
| SCHEMBL24486481 | 0.78 | CNR1 (0.47) | ALDH1A1SMN1; SMN2FABP3HPGDHTT | |
| SCHEMBL27796491 | 0.75 | RXFP1 (0.40) | ALDH1A1GAASMN1; SMN2FABP3HPGD | |
| SCHEMBL15070247 | 0.74 | KDM4E (0.50) | ALDH1A1SMN1; SMN2FABP3HPGDNPSR1 | |
| SCHEMBL27907524 | 0.73 | ALDH1A1 (0.43) | ALDH1A1GAASMN1; SMN2HPGDHTT | |
| SCHEMBL20681363 | 0.72 | ALDH1A1 (0.62) | ALDH1A1GAASMN1; SMN2MAPK13MAPK12 | |
| SCHEMBL10637926 | 0.72 | MEN1 (0.52) | ALDH1A1GAAMAPK13MAPK12MAPK11 | |
| SCHEMBL12000462 | 0.72 | KMT2A (0.53) | ALDH1A1GAAFABP3MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11351178-B2 | Selective HDAC6 inhibitors | ITALFARMACO SPA (IT) | 2022-06-07 | — | — | US | disclosed |
| US-20210128577-A1 | Selective HDAC6 Inhibitors | ITALFARMACO S.P.A. (IT) | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210128577-A1 | Selective HDAC6 Inhibitors | HDAC6, HDAC1, HDAC3 | ALDH1A1 104/4885GAA 90/4885SMN1; SMN2 1607/4885 |
| US-11351178-B2 | Selective HDAC6 inhibitors | HDAC6, HDAC1, HDAC3 | ALDH1A1 119/4885GAA 86/4885SMN1; SMN2 1667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.