Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1066829 | 0.83 | MAOB (0.50) | MAOBMAOACYP19A1CYP3A4CASP1 | |
| SCHEMBL22368803 | 0.80 | MAOA (0.47) | MAOBMAOACYP19A1CYP3A4CASP1 | |
| SCHEMBL10347651 | 0.79 | MAOA (0.46) | MAOBMAOACYP19A1CYP3A4CASP1 | |
| Bicarbonate SCHEMBL1066985 | 0.76 | MAOA (0.47) | MAOBMAOACYP19A1GRM2GRM3 | |
| SCHEMBL1867326 | 0.76 | GBA1 (0.62) | MAOBMAOACYP19A1GBA1 | |
| SCHEMBL22369104 | 0.75 | MAOB (0.46) | MAOBMAOACYP19A1CYP3A4CASP1 | |
| SCHEMBL10805321 | 0.71 | TAAR1 (0.44) | GBA1 | |
| SCHEMBL7654078 | 0.69 | GBA1 (0.48) | CCR3GBA1 | |
| SCHEMBL22170215 | 0.69 | MAOB (0.57) | MAOBMAOACYP19A1CYP3A4CASP1 | |
| SCHEMBL16187777 | 0.69 | GBA1 (0.53) | GRIN2BCCR3GBA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358720-A2 | FUSED RING HETEROARYL KINASE INHIBITORS | The Regents of the University of California (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010045542-A2 | FUSED RING HETEROARYL KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-22 | — | — | WO | disclosed |