Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.38 |
| ▸ | DRD3 | P35462 | 5/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13229794 | 0.90 | PDK1 (0.39) | DRD4PDK1ERBB2EPHA2KDR | |
| SCHEMBL16508846 | 0.87 | DRD4 (0.38) | DRD4DRD3PDK1ERBB2EPHA2 | |
| SCHEMBL29203384 | 0.85 | GBA1 (0.44) | DRD4DRD3PDK1ERBB2EPHA2 | |
| SCHEMBL29339652 | 0.82 | DRD3 (0.35) | DRD4DRD3HRH3DRD1 | |
| SCHEMBL23487054 | 0.82 | DRD4 (0.39) | DRD4DRD3PDK1ERBB2EPHA2 | |
| SCHEMBL15925118 | 0.82 | DRD4 (0.36) | DRD4DRD3PDK1ERBB2EPHA2 | |
| SCHEMBL29339653 | 0.82 | DRD3 (0.35) | DRD4DRD3HRH3DRD1 | |
| SCHEMBL25565643 | 0.82 | DRD3 (0.51) | DRD4DRD3DRD2 | |
| SCHEMBL25565642 | 0.82 | DRD3 (0.51) | DRD4DRD3DRD2 | |
| SCHEMBL9801156 | 0.82 | DRD3 (0.51) | DRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023218410-A1 | METHODS OF TREATING MYELOID MALIGNANCIES USING BCL-2 INHIBITOR | BEIGENE SWITZERLAND GMBH (CH) | 2023-11-16 | — | — | WO | disclosed |
| WO-2022256489-A1 | METHODS OF TREATING B-CELL MALIGNANCY USING BCL-2 INHIBITOR | BEIGENE, LTD. (KY) | 2022-12-08 | — | — | WO | disclosed |
| WO-2021208963-A1 | BCL-2 INHIBITOR | BEIGENE, LTD. (KY) | 2021-10-21 | — | — | WO | disclosed |
| WO-2021083135-A1 | Bcl-2 INHIBITORS | BEIGENE, LTD. (KY) | 2021-05-06 | — | — | WO | disclosed |