Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537530 | 0.81 | KMT2A (0.51) | KMT2ATDP1KDM3BMEN1RXFP1 | |
| SCHEMBL11343851 | 0.77 | KMT2A (0.51) | KMT2ATDP1KDM3BKDM4EFFAR3 | |
| SCHEMBL18640304 | 0.76 | KMT2A (0.50) | KMT2ATDP1KDM3BMEN1RXFP1 | |
| SCHEMBL21345745 | 0.76 | KMT2A (0.54) | KMT2ATDP1KDM3BMEN1RXFP1 | |
| SCHEMBL10735494 | 0.75 | KMT2A (0.50) | KMT2ATDP1KDM3BKDM4EFFAR3 | |
| SCHEMBL11458310 | 0.75 | DAO (0.50) | KMT2ATDP1KDM3BMEN1KDM4E | |
| SCHEMBL7007140 | 0.73 | HDAC8 (0.44) | KMT2ATDP1KDM3B | |
| SCHEMBL11456064 | 0.73 | DAO (0.44) | KMT2ATDP1KDM3BMEN1KDM4E | |
| SCHEMBL10979560 | 0.73 | DAO (0.44) | KMT2ATDP1KDM3BMEN1KDM4E | |
| SCHEMBL153562 | 0.72 | KMT2A (0.50) | KMT2ATDP1KDM3BUBE2NKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087408-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | OTONOMY, INC. (US) | 2021-05-06 | — | — | WO | disclosed |