Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10979560 | 0.90 | DAO (0.44) | DAOALDH1A1CYP2C9HPGDKMT2A | |
| SCHEMBL11456064 | 0.90 | DAO (0.44) | DAOALDH1A1CYP2C9HPGDKMT2A | |
| SCHEMBL4418633 | 0.85 | ALDH1A1 (0.53) | ALDH1A1CYP2C9HPGDKMT2AMEN1 | |
| SCHEMBL7007140 | 0.84 | HDAC8 (0.44) | DAOALDH1A1KMT2ATDP1KDM3B | |
| SCHEMBL10622918 | 0.82 | HRH4 (0.46) | DAOKMT2ATDP1PNP | |
| SCHEMBL23323385 | 0.75 | KMT2A (0.47) | KMT2ATDP1KDM3BKDM4EMEN1 | |
| SCHEMBL3537530 | 0.75 | KMT2A (0.51) | ALDH1A1KMT2ATDP1KDM3BKDM4E | |
| SCHEMBL11449106 | 0.72 | ALDH1A1 (0.65) | DAOALDH1A1CYP2C9HPGDSIRT2 | |
| SCHEMBL7008420 | 0.71 | DPYD (0.51) | ALDH1A1CYP2C9HPGDKMT2ATDP1 | |
| SCHEMBL11343851 | 0.71 | KMT2A (0.51) | ALDH1A1HPGDKMT2ATDP1KDM3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4218452-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-08-19 | — | — | US | disclosed |
| US-4159329-A | BLOCKING AGENTS, ANTAGONISTS, ANTIHISTAMINES | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-06-26 | — | — | US | disclosed |
| US-4145546-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-03-20 | — | — | US | disclosed |