Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexamethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.72 |
| ▸ | PGR | P06401 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | AR | P10275 | 2/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | APEX1 | P27695 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | IKBKB | O14920 | 1/20 | 0.72 |
| ▸ | CHUK | O15111 | 1/20 | 0.72 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.72 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.72 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.72 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triamcinolone SCHEMBL9396948 | 0.95 | NR3C1 (0.71) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL8666013 | 0.94 | HIF1A (0.68) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL8707845 | 0.94 | HIF1A (0.68) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL5970721 | 0.94 | NR3C1 (0.68) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 | |
| Testosterone Cypionate SCHEMBL9077493 | 0.88 | HIF1A (0.60) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 | |
| SCHEMBL24102598 | 0.85 | NR3C1 (0.60) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 | |
| SCHEMBL25863579 | 0.85 | NR3C1 (0.60) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 | |
| SCHEMBL25863572 | 0.85 | NR3C1 (0.62) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 | |
| SCHEMBL24103225 | 0.85 | NR3C1 (0.62) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL322760 | 0.85 | HIF1A (0.69) | NR3C1HIF1ACYP3A4HSD17B10NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534170-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | Pharmascience Inc. (CA) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011098904-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | AEGERA THERAPEUTICS, INC. (CA) | 2011-08-18 | — | — | WO | disclosed |
| EP-1750694-A4 | METABOLITES OF SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | UNIV TENNESSEE RES FOUNDATION (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1750694-A2 | METABOLITES OF SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | University of Tennessee Research Foundation (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113565-A2 | METABOLITES OF SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2005-12-01 | — | — | WO | disclosed |