Triamcinolone

SCHEMBL9396948

C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F.C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Triamcinolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	9/20	0.71

▸	CYP3A4	P08684	8/20	0.71

▸	HIF1A	Q16665	7/20	0.71

▸	HSD17B10	Q99714	7/20	0.71

▸	LMNA	P02545	7/20	0.71

▸	PGR	P06401	6/20	0.71

▸	NFKB1	P19838	3/20	0.71

▸	CYP2C9	P11712	3/20	0.71

▸	PMP22	Q01453	2/20	0.71

▸	CYP2J2	P51589	1/20	0.71

▸	BLM	P54132	1/20	0.71

▸	CYP2C19	P33261	1/20	0.71

▸	TSHR	P16473	4/20	0.63

▸	AR	P10275	4/20	0.63

▸	MEN1	O00255	1/20	0.63

▸	CYP2D6	P10635	1/20	0.63

▸	KMT2A	Q03164	1/20	0.63

▸	APEX1	P27695	1/20	0.63

▸	NPSR1	Q6W5P4	1/20	0.63

▸	IKBKB	O14920	1/20	0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Dexamethasone SCHEMBL2332532	0.95	NR3C1 (0.72)	NR3C1CYP3A4HIF1AHSD17B10LMNA
Dexamethasone SCHEMBL8666013	0.88	HIF1A (0.68)	NR3C1CYP3A4HIF1AHSD17B10LMNA
Dexamethasone SCHEMBL5970721	0.88	NR3C1 (0.68)	NR3C1CYP3A4HIF1AHSD17B10LMNA
Dexamethasone SCHEMBL8707845	0.88	HIF1A (0.68)	NR3C1CYP3A4HIF1AHSD17B10LMNA
Triamcinolone SCHEMBL9837854	0.86	HIF1A (0.66)	NR3C1CYP3A4HIF1AHSD17B10LMNA
Triamcinolone SCHEMBL593313	0.85	HIF1A (0.68)	NR3C1CYP3A4HIF1AHSD17B10LMNA
Triamcinolone SCHEMBL24622562	0.84	NR3C1 (1.00)	NR3C1CYP3A4HIF1AHSD17B10LMNA
Triamcinolone SCHEMBL4447	0.84	NR3C1 (1.00)	NR3C1CYP3A4HIF1AHSD17B10LMNA
Triamcinolone SCHEMBL9863653	0.84	NR3C1 (1.00)	NR3C1CYP3A4HIF1AHSD17B10LMNA
Triamcinolone SCHEMBL22962813	0.84	NR3C1 (1.00)	NR3C1CYP3A4HIF1AHSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-1994022424-A1	BIODEGRADABLE, WATER-PERMEABLE MEMBRANE FOR FLUID-IMBIBING PUMP	ALZA CORPORATION (US)	1994-10-13	—	—	WO	disclosed