⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27555648 | 0.78 | CHRNB2 (0.40) | — | |
| SCHEMBL9512873 | 0.78 | CHRNB2 (0.43) | — | |
| SCHEMBL652699 | 0.77 | CHRNB2 (0.42) | — | |
| SCHEMBL27852738 | 0.77 | CHRNB2 (0.39) | — | |
| SCHEMBL103866 | 0.76 | — | — | |
| SCHEMBL1615800 | 0.76 | CHRNB2 (0.58) | — | |
| SCHEMBL105805 | 0.76 | — | — | |
| SCHEMBL6236654 | 0.76 | TDP1 (0.39) | — | |
| SCHEMBL8903486 | 0.76 | — | — | |
| SCHEMBL16846175 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101304978-B | Quinazoline derivative as multi-component inhibitor, pharmaceutical composition and application | HANMI PHARM IND CO LTD | 2012-12-26 | — | — | CN | disclosed |
| EP-2358397-A2 | 5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom | Isis Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| EP-2358398-A2 | OLIGOMERIC COMPOUNDS AND METHODS | Isis Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010048549-A2 | 5' AND 2' BIS-SUBSTITUTED NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048585-A2 | OLIGOMERIC COMPOUNDS AND METHODS | ISIS PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| CN-101304978-A | Quinazoline derivatives as multiplex inhibitors and process for their preparation | HANMI PHARM IND CO LTD (KR) | 2008-11-12 | — | — | CN | disclosed |
| WO-1984004302-A1 | SUBSTITUTED PICOLINIC ACIDS, PROCESSES FOR THEIR PREPARATION, THEIR USE AND MEDICAMENTS CONTAINING THEM | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-08 | — | — | WO | disclosed |