Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23330747 | 0.88 | MIF (0.47) | MIFFLT3PIK3CAPRMT5WDR77 | |
| SCHEMBL23300731 | 0.87 | PIK3CA (0.45) | MIFFLT3PIK3CAPRMT5WDR77 | |
| SCHEMBL23331132 | 0.85 | MIF (0.48) | MIFFLT3PIK3CAPRMT5WDR77 | |
| SCHEMBL29831257 | 0.73 | MIF (0.45) | MIFFLT3PIK3CAPRMT5WDR77 | |
| SCHEMBL23330745 | 0.71 | FLT3 (0.51) | MIFFLT3PIK3CAPRMT5WDR77 | |
| SCHEMBL23331141 | 0.68 | HPGD (0.41) | MIFIKBKETBK1HPGDSMN1; SMN2 | |
| SCHEMBL23330937 | 0.68 | IMPDH2 (0.45) | GSK3BHSD17B10 | |
| SCHEMBL24721624 | 0.68 | MAPK8 (0.40) | MIFFLT3PIK3CAPRMT5WDR77 | |
| SCHEMBL2650330 | 0.67 | FLT3 (0.74) | MIFFLT3PIK3CAKDRKIT | |
| SCHEMBL16675756 | 0.67 | MIF (0.59) | MIFFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021083060-A1 | FIVE-MEMBERED HETEROCYCLIC OXOCARBOXYLIC ACID COMPOUND AND MEDICAL USE THEREOF | 中国科学院上海药物研究所 | 2021-05-06 | — | — | WO | disclosed |