Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23392921 | 1.00 | RAB9A (0.43) | RAB9AL3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23392919 | 1.00 | RAB9A (0.43) | RAB9AL3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL17276528 | 0.82 | MAPT (0.55) | RAB9AL3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL25581428 | 0.81 | RXFP1 (0.42) | L3MBTL1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL27045464 | 0.79 | ALDH1A1 (0.63) | RAB9AL3MBTL1ALDH1A1MAPTMEN1 | |
| SCHEMBL16595860 | 0.78 | MAPT (0.43) | RAB9AL3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL21164826 | 0.78 | ALDH1A1 (0.37) | RAB9AL3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL25581431 | 0.78 | KMT2A (0.49) | RAB9AALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL24000933 | 0.77 | ALDH1A1 (0.44) | RAB9AL3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL15177203 | 0.73 | ALDH1A1 (0.54) | RAB9AL3MBTL1ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212644-B1 | DERIVATIVES OF 2-(1,2,4-TRIAZOL-3-YLSULFANYL)-N-1,3,4-THIADIAZOL-2-YL ACETAMIDE WHICH ARE USEFUL FOR THE TREATMENT OF DIABETES | APOGLYX AB (SE) | 2021-05-05 | — | — | EP | disclosed |