Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CDC25A | P30304 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19549066 | 0.92 | LMNA (0.75) | LMNAHTTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL19566993 | 0.84 | LMNA (0.77) | LMNAHTTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL17725778 | 0.82 | LMNA (0.73) | LMNAHTTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL19549101 | 0.82 | LMNA (0.73) | LMNAHTTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL19549109 | 0.81 | TSHR (0.62) | LMNAHTTALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19549075 | 0.81 | ALDH1A1 (0.66) | LMNAHTTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL19566983 | 0.79 | TSHR (0.61) | LMNAHTTALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19549103 | 0.79 | TSHR (0.61) | LMNAHTTALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19549110 | 0.79 | LMNA (0.62) | LMNAHTTALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19566995 | 0.79 | LMNA (0.62) | LMNAHTTALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212644-B1 | DERIVATIVES OF 2-(1,2,4-TRIAZOL-3-YLSULFANYL)-N-1,3,4-THIADIAZOL-2-YL ACETAMIDE WHICH ARE USEFUL FOR THE TREATMENT OF DIABETES | APOGLYX AB (SE) | 2021-05-05 | — | — | EP | disclosed |