Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | P2RY1 | P47900 | 14/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29991644 | 1.00 | MEN1 (0.63) | MEN1CYP1A2KMT2AKDM4ECYP2C19 | |
| SCHEMBL30166677 | 1.00 | MEN1 (0.63) | MEN1CYP1A2KMT2AKDM4ECYP2C19 | |
| SCHEMBL10969027 | 0.88 | KDM4E (0.62) | MEN1CYP1A2KMT2AKDM4ECYP2C19 | |
| SCHEMBL8177633 | 0.88 | KDM4E (0.62) | MEN1CYP1A2KMT2AKDM4ECYP2C19 | |
| SCHEMBL2785360 | 0.86 | TDP1 (0.54) | MEN1CYP1A2KMT2AKDM4ECYP2C19 | |
| SCHEMBL9122123 | 0.86 | TDP1 (0.66) | MEN1CYP1A2KMT2AKDM4ECYP2C19 | |
| SCHEMBL135002 | 0.85 | P2RY1 (0.72) | MEN1CYP1A2KMT2AKDM4ECYP2C19 | |
| SCHEMBL29549324 | 0.85 | P2RY1 (0.72) | MEN1CYP1A2KMT2AKDM4ECYP2C19 | |
| SCHEMBL7372993 | 0.84 | TDP1 (0.52) | MEN1CYP1A2KMT2AKDM4ECYP2C19 | |
| SCHEMBL7375948 | 0.83 | KDM4E (0.57) | MEN1CYP1A2KMT2AKDM4ECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230346765-A1 | METHODS OF TREATING XANTHINE OXIDASE-RELATED DISEASES WITH NIFLUMIC ACID AND DERIVATIVES THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2023-11-02 | — | — | US | disclosed |
| US-20230346765-A1 | METHODS OF TREATING XANTHINE OXIDASE-RELATED DISEASES WITH NIFLUMIC ACID AND DERIVATIVES THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2023-11-02 | — | — | US | disclosed |
| EP-4121052-A1 | METHODS OF TREATING XANTHINE OXIDASE-RELATED DISEASES WITH NIFLUMIC ACID AND DERIVATIVES THEREOF | Baylor College of Medicine (US) | 2023-01-25 | — | — | EP | disclosed |
| CN-113171742-B | A agitating unit for diflufenican production | 浙江南郊化学有限公司 | 2022-10-11 | — | — | CN | disclosed |
| WO-2021188296-A1 | METHODS OF TREATING XANTHINE OXIDASE-RELATED DISEASES WITH NIFLUMIC ACID AND DERIVATIVES THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2021-09-23 | — | — | WO | disclosed |
| CN-113171742-A | A agitating unit for diflufenican production | 浙江南郊化学有限公司 | 2021-07-27 | — | — | CN | disclosed |
| US-8309734-B2 | Substituted pyridines as GPBAR1 agonists | HOFFMANN-LA ROCHE INC. (US) | 2012-11-13 | — | — | US | disclosed |
| EP-2356094-A1 | NOVEL PHENYL AMIDE OR PYRIDIL AMIDE DERIVATIVES AND THEIR USE AS GPBAR1 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010091104-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | EXELIXIS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |
| CN-101709052-A | Preparation method of 2-(3-trifluoromethyl phenoxy) niacin | NANJING FIRST AGRICULTURAL CHE | 2010-05-19 | — | — | CN | disclosed |
| US-20100105906-A1 | NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2010-04-29 | — | — | US | disclosed |
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| WO-2001023356-A1 | SUBSTITUTED N-PHENYL-PHENOXY NICOTINIC ACID-(THIO) AMIDES AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-04-05 | — | — | WO | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |
| US-4618366-A | Certain N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)-nicotinamides having herbicidal activity | MAY & BAKER LIMITED (GB) | 1986-10-21 | — | — | US | disclosed |
| EP-0053011-B1 | NEW HERBICIDAL NICOTINAMIDE DERIVATIVES | MAY & BAKER LIMITED (GB) | 1985-04-03 | — | — | EP | disclosed |
| EP-0053011-A1 | New herbicidal nicotinamide derivatives | MAY & BAKER LIMITED (GB) | 1982-06-02 | — | — | EP | disclosed |
| US-4327218-A | HERBICIDES | STAUFFER CHEMICAL COMPANY (US) | 1982-04-27 | — | — | US | disclosed |
| US-4251263-A | N-substituted, 2-phenoxynicotinamide compounds and the herbicidal use thereof | STAUFFER CHEMICAL COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230346765-A1 | METHODS OF TREATING XANTHINE OXIDASE-RELATED DISEASES WITH NIFLUMIC ACID AND DERIVATIVES THEREOF | XDH, PNPO, PNP | MEN1 3315/4885CYP1A2 785/4885KMT2A 4069/4885 |
| US-20100105906-A1 | NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES | GPBAR1, GPR119, GLP1R | MEN1 3165/4885CYP1A2 296/4885KMT2A 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.