Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.56 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.52 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 5/20 | 0.40 |
| ▸ | RXRB | P28702 | 5/20 | 0.40 |
| ▸ | RXRG | P48443 | 5/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.38 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337996 | 0.92 | LPAR1 (0.46) | LPAR1LPAR3LPAR2MAPTHDAC1 | |
| SCHEMBL2341771 | 0.89 | LPAR1 (0.60) | LPAR1LPAR3LPAR2MAPTENPP2 | |
| SCHEMBL1286658 | 0.87 | LPAR1 (0.68) | LPAR1LPAR3LPAR2MAPTENPP2 | |
| SCHEMBL2761503 | 0.87 | LPAR1 (0.42) | LPAR1LPAR3LPAR2MAPTFFAR4 | |
| SCHEMBL2338531 | 0.87 | LPAR1 (0.61) | LPAR1LPAR3LPAR2MAPTENPP2 | |
| SCHEMBL2761308 | 0.86 | LPAR1 (0.43) | LPAR1LPAR3LPAR2MAPTFFAR4 | |
| SCHEMBL1247197 | 0.86 | NTRK1 (0.41) | LPAR1RXRARXRBRXRGENPP2 | |
| SCHEMBL2635833 | 0.86 | LPAR1 (0.56) | LPAR1LPAR3LPAR2MAPTMGLL | |
| SCHEMBL2761438 | 0.84 | LPAR1 (0.39) | LPAR1LPAR3LPAR2MAPTHDAC1 | |
| SCHEMBL3714449 | 0.84 | LPAR1 (0.58) | LPAR1LPAR3LPAR2MAPTENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | claimed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |