Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.62 |
| ▸ | HTR1A | P08908 | 5/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
| ▸ | NMT1 | P30419 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6905082 | 0.86 | ALDH1A1 (0.48) | HRH1HTR1ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL1134126 | 0.82 | MCHR1 (0.50) | HRH1HTR1ASLC6A2SLC6A3 | |
| SCHEMBL29527476 | 0.81 | MCHR1 (0.53) | HRH1 | |
| SCHEMBL3799059 | 0.81 | MCHR1 (0.53) | HRH1 | |
| SCHEMBL17738695 | 0.80 | HRH1 (0.49) | HRH1HTR1ASLC6A2SLC6A3SLC6A4 | |
| Aniline SCHEMBL22169159 | 0.79 | ALDH1A1 (0.42) | HRH1HTR1ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL234010 | 0.78 | SLC6A2 (0.81) | HRH1HTR1ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL3798831 | 0.78 | KAT2B (0.53) | HRH1 | |
| SCHEMBL358791 | 0.78 | ALDH1A1 (0.41) | HRH1HTR1ASLC6A2SLC6A3 | |
| SCHEMBL82955 | 0.78 | HRH1 (0.62) | HRH1HTR1ASLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358697-A1 | Isoindoline compounds for use in the treatment of cancer | CELGENE CORPORATION (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010053732-A1 | ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | CELGENE CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |
| US-4810792-A | HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-03-07 | — | — | US | disclosed |
| US-4788201-A | HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0275962-A2 | 3-Methylenespiro [benzofuran-piperidines], intermediates and a process for the preparation thereof, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-07-27 | — | — | EP | disclosed |