Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23340697 | 0.82 | MEN1 (0.40) | POLBSMN1; SMN2HTTALDH1A1EPHX2 | |
| SCHEMBL23340478 | 0.77 | NUDT5 (0.46) | POLBSIRT5SOS1HTR2CSMN1; SMN2 | |
| SCHEMBL23297593 | 0.77 | DPP4 (0.60) | POLBSIRT5DPP4ALDH1A1FAP | |
| SCHEMBL23340704 | 0.76 | NUDT5 (0.56) | POLBSIRT5SOS1HTR2CDPP4 | |
| SCHEMBL23340497 | 0.75 | NUDT5 (0.47) | HTR2CSMN1; SMN2HTTDPP4NPC1 | |
| SCHEMBL23340639 | 0.74 | NUDT5 (0.47) | POLBHTR3ASOS1HTR2CSMN1; SMN2 | |
| SCHEMBL23340491 | 0.74 | HTR2C (0.43) | POLBSIRT5SOS1HTR2CDPP4 | |
| SCHEMBL23340553 | 0.74 | NUDT5 (0.47) | POLBHTR3AHTR2CSMN1; SMN2HTT | |
| SCHEMBL23340461 | 0.73 | NUDT5 (0.46) | HTR3AHTR2CALDH1A1TP53TSHR | |
| SCHEMBL23340469 | 0.72 | NUDT5 (0.46) | HTR2CNUDT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210128566-A1 | NOVEL FUNCTIONALIZED PURINE-2,6-DIONES AND THEIR USE IN MEDICINE | THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210128566-A1 | NOVEL FUNCTIONALIZED PURINE-2,6-DIONES AND THEIR USE IN MEDICINE | ADORA2A, HPRT1, PNP | POLB 573/4885SIRT5 2024/4885HTR3A 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.