Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232158 | 0.88 | HPGD (0.60) | HPGDTSHRALOX15CHRM2CHRM4 | |
| SCHEMBL2338174 | 0.81 | SRD5A1 (0.47) | HPGDTSHRTACR1PRKG1ALOX15 | |
| SCHEMBL27396701 | 0.79 | ALOX15 (0.61) | TACR1PRKG1ALOX15KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8569868 | 0.78 | ALOX15 (0.59) | TACR1PRKG1ALOX15KDM4EALDH1A1 | |
| SCHEMBL2231867 | 0.74 | HPGD (0.44) | HPGDTSHRALDH1A1NLRP3 | |
| SCHEMBL11123316 | 0.73 | HPGD (0.53) | HPGDTSHRPRMT5WDR77CHRM2 | |
| SCHEMBL3038179 | 0.73 | HPGD (0.56) | HPGDTSHRPRMT5WDR77CHRM2 | |
| SCHEMBL3048725 | 0.73 | PRMT5 (0.54) | HPGDTSHRPRMT5WDR77CHRM2 | |
| SCHEMBL2360299 | 0.71 | HCRTR1 (0.44) | HPGDTSHRPRMT5WDR77CHRM2 | |
| SCHEMBL14171910 | 0.71 | PDE5A (0.40) | TACR1PRKG1ALOX15HTR2BTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |