Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232158 | 0.86 | HPGD (0.60) | HPGDTSHRNLRP3PDE4APDE4B | |
| SCHEMBL5405962 | 0.83 | HPGD (0.39) | HPGDTSHRNLRP3PDE4APDE4B | |
| SCHEMBL24725913 | 0.79 | HPGD (0.58) | HPGDTSHRPDE4APDE4BPDE4C | |
| SCHEMBL2333026 | 0.79 | QPCT (0.37) | HPGDTSHRGRM5 | |
| SCHEMBL12471409 | 0.79 | ALOX15 (0.37) | HPGDTSHRGRM5ALDH1A1 | |
| SCHEMBL2334866 | 0.78 | DPP4 (0.41) | HPGDTSHR | |
| SCHEMBL24725852 | 0.76 | ALDH1A1 (0.55) | HPGDTSHRPDE4APDE4BPDE4C | |
| SCHEMBL2957523 | 0.76 | HPGD (0.48) | HPGDTSHRPDE4APDE4BPDE4C | |
| SCHEMBL2334074 | 0.74 | HPGD (0.45) | HPGDTSHRNLRP3ALDH1A1 | |
| SCHEMBL2338174 | 0.74 | SRD5A1 (0.47) | HPGDTSHRNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346500-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010044878-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-04-22 | — | — | WO | disclosed |