Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | REN | P00797 | 5/20 | 0.56 |
| ▸ | APP | P05067 | 4/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11096532 | 1.00 | ACE (0.58) | ACEATMRENAPPKLK5 | |
| SCHEMBL13995497 | 0.84 | ATM (0.68) | ACEATMRENAPPMAPK1 | |
| SCHEMBL13995499 | 0.84 | ATM (0.68) | ACEATMRENAPPMAPK1 | |
| SCHEMBL18229266 | 0.83 | REN (0.71) | ACERENMAPK1MME | |
| SCHEMBL3498474 | 0.83 | REN (0.71) | ACERENMAPK1MME | |
| SCHEMBL24224252 | 0.83 | REN (0.71) | ACERENMAPK1MME | |
| SCHEMBL7269523 | 0.83 | REN (0.71) | ACERENMAPK1MME | |
| SCHEMBL28611118 | 0.83 | REN (0.71) | ACERENMAPK1MME | |
| SCHEMBL12242944 | 0.83 | REN (0.71) | ACERENMAPK1MME | |
| SCHEMBL24387806 | 0.82 | ATM (0.65) | ACEATMAPPKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086069-A1 | COMPOUND COMPRISING EZH2 INHIBITOR AND E3 LIGASE BINDER AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING EZH2-ASSOCIATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT | 재단법인 대구경북첨단의료산업진흥재단 | 2021-05-06 | — | — | WO | disclosed |