Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 5/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23995664 | 0.88 | ALDH1A1 (0.37) | ALDH1A1CYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL25093262 | 0.81 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL23344999 | 0.79 | CYP1A2 (0.39) | ALDH1A1CYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL24341884 | 0.77 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL23345012 | 0.77 | CYP2C9 (0.46) | ALDH1A1CYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL277929 | 0.77 | ALDH1A1 (0.55) | ALDH1A1CYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL25810288 | 0.77 | ALDH1A1 (0.55) | ALDH1A1CYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL14010813 | 0.75 | — | — | |
| SCHEMBL8402970 | 0.75 | ALDH1A1 (0.51) | ALDH1A1CYP1A2CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL13722312 | 0.75 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2D6CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168102-B1 | Bicyclic heteroaryl compounds and uses thereof | Revolution Medicines, Inc. (US) | 2021-11-09 | — | — | US | disclosed |
| US-20210139517-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | Revolution Medicines, Inc. | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11168102-B1 | Bicyclic heteroaryl compounds and uses thereof | SOS1, SOST, SOS2 | ALDH1A1 3199/4885CYP1A2 1997/4885CYP2D6 1512/4885 |
| US-20210139517-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | SOST, SOS1, SOS2 | ALDH1A1 3594/4885CYP1A2 2086/4885CYP2D6 1282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.