Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23077821 | 0.88 | CYP1A2 (0.43) | CYP2C19ALDH1A1MAPK1USP2OPRM1 | |
| SCHEMBL350018 | 0.84 | OPRM1 (0.38) | CYP4F2CYP4A11CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL23075986 | 0.83 | SMN1; SMN2 (0.45) | CYP4F2CYP4A11CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL18069128 | 0.82 | SMN1; SMN2 (0.42) | CYP4F2CYP4A11CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL25093263 | 0.77 | USP2 (0.42) | CYP2C19ALDH1A1MAPK1USP2HPGD | |
| SCHEMBL23345238 | 0.74 | SMN1; SMN2 (0.38) | CYP2C19ALDH1A1MAPK1USP2OPRM1 | |
| SCHEMBL16888554 | 0.73 | CYP1A2 (0.41) | CYP2C19ALDH1A1MAPK1USP2HPGD | |
| SCHEMBL18478135 | 0.72 | SMN1; SMN2 (0.43) | CYP2C19ALDH1A1MAPK1USP2HPGD | |
| SCHEMBL14297361 | 0.72 | SMN1; SMN2 (0.43) | CYP2C19ALDH1A1MAPK1USP2HPGD | |
| SCHEMBL23309174 | 0.72 | CYP1A2 (0.44) | CYP2C19ALDH1A1MAPK1USP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168102-B1 | Bicyclic heteroaryl compounds and uses thereof | Revolution Medicines, Inc. (US) | 2021-11-09 | — | — | US | disclosed |
| US-20210139517-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | Revolution Medicines, Inc. | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11168102-B1 | Bicyclic heteroaryl compounds and uses thereof | SOS1, SOST, SOS2 | CYP4F2 586/4885CYP4A11 305/4885CYP2C19 3214/4885 |
| US-20210139517-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | SOST, SOS1, SOS2 | CYP4F2 951/4885CYP4A11 696/4885CYP2C19 3440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.