Sugi Predict

Sugi Predict / Compounds / SCHEMBL2335338

SCHEMBL2335338

SCHEMBL2335338

C[Si](C)(C)Oc1ccc(N)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.52
▸ MAPK1 P28482 2/20 0.52
▸ ALDH1A1 P00352 8/20 0.50
▸ CYP3A4 P08684 2/20 0.50
▸ TSHR P16473 2/20 0.50
▸ TEAD4 Q15561 1/20 0.46
▸ MAPT P10636 6/20 0.44
▸ POLB P06746 1/20 0.44
▸ SMN1; SMN2 Q16637 3/20 0.44
▸ NPC1 O15118 2/20 0.44
▸ HPGD P15428 2/20 0.44
▸ RAB9A P51151 2/20 0.44
▸ KDM4E B2RXH2 1/20 0.44
▸ TP53 P04637 1/20 0.44
▸ NFKB1 P19838 1/20 0.44
▸ NFKB2 Q00653 1/20 0.44
▸ RELA Q04206 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.44
▸ MAOA P21397 2/20 0.42
▸ MEN1 O00255 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9827079 0.87 GFER (0.56) TDP1MAPK1ALDH1A1CYP3A4TSHR
SCHEMBL4763549 0.86 CA1 (0.39) TDP1MAPK1ALDH1A1MEN1KMT2A
SCHEMBL357605 0.84 TDP1 (0.52) TDP1MAPK1ALDH1A1CYP3A4TSHR
SCHEMBL15375276 0.82 TDP1 (0.56) TDP1MAPK1ALDH1A1CYP3A4TSHR
SCHEMBL28446580 0.81 TDP1 (0.44) TDP1MAPK1ALDH1A1CYP3A4TSHR
SCHEMBL3309381 0.80 TDP1 (0.48) TDP1MAPK1ALDH1A1CYP3A4TSHR
SCHEMBL28889036 0.78 TDP1 (0.46) TDP1MAPK1ALDH1A1CYP3A4TSHR
SCHEMBL3358721 0.78 ALDH1A1 (0.50) TDP1MAPK1ALDH1A1CYP3A4TSHR
SCHEMBL8722725 0.78 TDP1 (0.46) TDP1MAPK1ALDH1A1CYP3A4TSHR
SCHEMBL17881929 0.78 ESR2 (0.39) TDP1MAPK1ALDH1A1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4695236-A1 SUBSTITUTED PHENYL-PIPERAZINYL BASED MODULATORS FOR THE TREATMENT OF DISEASE Soley Therapeutics, Inc. (US) 2026-02-18 — — EP disclosed
WO-2024216094-A1 SUBSTITUTED PHENYL-PIPERAZINYL BASED MODULATORS FOR THE TREATMENT OF DISEASE SOLEY THERAPEUTICS, INC. (US) 2024-10-17 — — WO disclosed
CN-110099974-B Composition for forming protective layer on substrate 日产化学株式会社 2022-02-25 — — CN disclosed
CN-111423813-B Composition for forming release layer and release layer 日产化学工业株式会社 2021-11-23 — — CN disclosed
CN-107406675-B Composition for forming release layer and release layer 日产化学工业株式会社 2020-11-06 — — CN disclosed
CN-111423813-A Composition for forming release layer and release layer 日产化学工业株式会社 2020-07-17 — — CN disclosed
US-9018377-B2 Hydrogen peroxide sensors based upon photo-induced electron transfer OPTI MEDICAL SYSTEMS (US) 2015-04-28 — — US disclosed
US-9018377-B2 Hydrogen peroxide sensors based upon photo-induced electron transfer OPTI MEDICAL SYSTEMS (US) 2015-04-28 — — US disclosed
US-20130046103-A1 PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES MAPI PHARMA LIMITED (IL) 2013-02-21 — — US disclosed
EP-2533636-A1 PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES Mapi Pharma Limited (IL) 2012-12-19 — — EP disclosed
EP-1254117-A1 NON-SYMMETRICAL LIGANDS AND CATALYST SYSTEMS THEREOF FOR EHTYLENE OLIGOMERISATION TO LINEAR ALPHA OLEFINS SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 2002-11-06 — — EP disclosed
US-20020016425-A1 Non-symmetrical ligands and catalyst systems thereof for ethylene oligomerisation to linear alpha olefins SHELL OIL COMPANY 2002-02-07 — — US disclosed
WO-2001058874-A1 NON-SYMMETRICAL LIGANDS AND CATALYST SYSTEMS THEREOF FOR EHTYLENE OLIGOMERISATION TO LINEAR ALPHA OLEFINS SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 2001-08-16 — — WO disclosed
US-5656264-A ADMINISTERING TO THE SCALP OF THE MALE A PREPERATION CONSITING OF 6-BENZYLAMINOPURINE SANSYO SEIYAKU CO., LTD. (JP) 1997-08-12 — — US disclosed
EP-0540854-A2 Preparation for promoting hair growth Sansho Seiyaku Co., Ltd. (JP) 1993-05-12 — — EP disclosed
US-4946990-A CHEMICAL INTERMEDIATE FOR THE PRODUCTION OF POLYURETHANES BAYER AKTIENGESELLSCHAFT (DE) 1990-08-07 — — US disclosed
US-4886902-A HEATING POLYISOCYANATE AND AMINE WITH SILYLATED HYDROXYL GROUP; REACTING ISOCYANATE-ACID HALIDE WITH PRODUCT BAYER AKTIENGESELLSCHAFT (DE) 1989-12-12 — — US disclosed
US-4870198-A SILYLATED ALCOHOL OR CARBOXYL GROUPS BAYER AKTIENGESELLSCHAFT (DE) 1989-09-26 — — US disclosed
EP-0307763-A2 Process for the preparation of polyisocyanates BAYER AG (DE) 1989-03-22 — — EP disclosed
EP-0307756-A2 Process for the preparation of isocyanates and their use in the preparation of polyisocyanates containing ester groups, and some polyisocyanates containing these ester groups BAYER AG (DE) 1989-03-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130046103-A1 PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES CYP2F1, CYP4F3, CYP2D6 TDP1 4036/4885MAPK1 2578/4885ALDH1A1 1830/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.