Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2338221 | 0.98 | SLC6A4 (0.50) | MAOAMAOBTAAR1SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL29428978 | 0.86 | SLC6A4 (0.44) | MAOAMAOBTAAR1SLC6A4SLC6A3 | |
| SCHEMBL8185838 | 0.81 | DPP4 (0.64) | SLC6A4SLC6A3SLC6A2DPP4 | |
| SCHEMBL14482778 | 0.81 | DPP4 (0.64) | SLC6A4SLC6A3SLC6A2DPP4 | |
| SCHEMBL805454 | 0.79 | GRIN1 (0.50) | TAAR1SLC6A4SLC6A3HTR2A | |
| SCHEMBL17761216 | 0.76 | HDAC4 (0.45) | SLC6A4 | |
| SCHEMBL24018816 | 0.75 | SLC6A3 (0.54) | MAOAMAOBTAAR1SLC6A4SLC6A3 | |
| SCHEMBL14920764 | 0.75 | TAAR1 (0.52) | MAOAMAOBTAAR1SLC6A4SLC6A3 | |
| SCHEMBL11480787 | 0.75 | TAAR1 (0.52) | MAOAMAOBTAAR1SLC6A4SLC6A3 | |
| SCHEMBL17187886 | 0.72 | SLC6A3 (0.83) | MAOAMAOBTAAR1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358716-B1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | MERCK SHARP & DOHME (US) | 2016-01-06 | — | — | EP | disclosed |
| EP-2485735-B1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | MERCK SHARP & DOHME (US) | 2015-07-29 | — | — | EP | disclosed |
| US-8815875-B2 | Inhibitors of fatty acid binding protein (FABP) | MERCK SHARP & DOHME CORP. (US) | 2014-08-26 | — | — | US | disclosed |
| US-20110237575-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | MERCK SHARP & DOHME LLC | 2011-09-29 | — | — | US | disclosed |
| EP-2358716-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | Schering Corporation (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010056631-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | SCHERING CORPORATION (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237575-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) | FABP4, FABP1, FABP3 | MAOA 3482/4885MAOB 2364/4885TAAR1 3865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.