Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23355389 | 0.90 | KDM4E (0.36) | KDM4EKMT2ACA1CA2CA9 | |
| SCHEMBL23355470 | 0.90 | KDM4E (0.36) | KDM4EKMT2ACA1CA2CA9 | |
| SCHEMBL23355422 | 0.84 | ADORA1 (0.34) | KDM4EKMT2AHPGDSMN1; SMN2TP53 | |
| SCHEMBL23355413 | 0.80 | LRRK2 (0.40) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL30203115 | 0.76 | EGFR (0.48) | — | |
| SCHEMBL21616332 | 0.76 | EGFR (0.48) | — | |
| SCHEMBL21616259 | 0.76 | KDM4E (0.48) | KDM4EKMT2ANPC1RAB9AHPGD | |
| SCHEMBL23355355 | 0.72 | LRRK2 (0.32) | — | |
| SCHEMBL15877172 | 0.72 | SLC2A1 (0.43) | KDM4EKMT2ANPC1HPGDTP53 | |
| SCHEMBL15391603 | 0.70 | MAPT (0.48) | KDM4EKMT2ATP53MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822263-A1 | BIARYL ETHER-TYPE QUINAZOLINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2021-05-19 | — | — | EP | disclosed |