Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.68 |
| ▸ | JAK2 | O60674 | 11/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.47 |
| ▸ | JAK3 | P52333 | 7/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670155 | 1.00 | KCNH2 (0.68) | KCNH2JAK2NTRK1JAK3AURKA | |
| SCHEMBL2341964 | 0.86 | KCNH2 (0.54) | KCNH2JAK2NTRK1JAK3AURKA | |
| SCHEMBL3668292 | 0.86 | KCNH2 (0.54) | KCNH2JAK2NTRK1JAK3AURKA | |
| SCHEMBL2334912 | 0.82 | NTRK1 (0.59) | KCNH2JAK2NTRK1JAK3AURKA | |
| SCHEMBL588686 | 0.80 | JAK3 (0.68) | JAK2NTRK1JAK3AURKALCK | |
| SCHEMBL3950465 | 0.76 | NTRK1 (0.53) | KCNH2JAK2NTRK1JAK3AURKA | |
| SCHEMBL4983768 | 0.74 | JAK3 (0.68) | JAK2NTRK1JAK3AURKALCK | |
| SCHEMBL4984204 | 0.74 | JAK2 (0.50) | KCNH2JAK2NTRK1JAK3AURKA | |
| SCHEMBL4984208 | 0.74 | JAK2 (0.50) | KCNH2JAK2NTRK1JAK3AURKA | |
| SCHEMBL3669132 | 0.72 | JAK2 (0.52) | KCNH2JAK2NTRK1JAK3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152702-B1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2011-08-24 | — | — | EP | disclosed |
| US-20100204231-A1 | AMINO-THIAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204231-A1 | AMINO-THIAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | THPO, TYMP, TPMT | KCNH2 3980/4885JAK2 8/4885NTRK1 4491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.