Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dydrogesterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 4/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.96 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.96 |
| ▸ | AR | P10275 | 2/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.96 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.96 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.61 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dydrogesterone SCHEMBL23360793 | 1.00 | CYP3A4 (0.96) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL11512798 | 0.98 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL606817 | 0.98 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL606816 | 0.98 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL18814051 | 0.98 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL37703 | 0.98 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL23383832 | 0.98 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL23360787 | 0.98 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL20281282 | 0.98 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL13907084 | 0.98 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021093494-A1 | PRODUCTION PROCESS CAPABLE OF INDUSTRIALLY SYNTHESIZING DYDROGESTERONE | 广西师范大学 | 2021-05-20 | — | — | WO | disclosed |