Dydrogesterone

Dydrogesterone

SCHEMBL606816

CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@H]3CC[C@]12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PGR

The experimentally established mechanism targets of Dydrogesterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR known ✓ P06401 4/20 1.00
CYP3A4 P08684 5/20 1.00
ALDH1A1 P00352 3/20 1.00
CYP2C19 P33261 2/20 1.00
AR P10275 2/20 1.00
CHRM1 P11229 2/20 1.00
ADRA1A P35348 2/20 1.00
TBXA2R P21731 1/20 1.00
CYP19A1 P11511 3/20 0.63
SERPINA6 P08185 4/20 0.59
LMNA P02545 3/20 0.59
NR3C1 P04150 3/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
CYP2C9 P11712 2/20 0.59
TSHR P16473 2/20 0.59
HIF1A Q16665 2/20 0.59
MAPT P10636 2/20 0.59
MAPK1 P28482 2/20 0.59
MEN1 O00255 2/20 0.59
CHRM2 P08172 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dydrogesterone SCHEMBL29335245 1.00 CYP3A4 (1.00) CYP3A4PGRALDH1A1CYP2C19AR
Dydrogesterone SCHEMBL13907084 1.00 CYP3A4 (1.00) CYP3A4PGRALDH1A1CYP2C19AR
Dydrogesterone SCHEMBL37703 1.00 CYP3A4 (1.00) CYP3A4PGRALDH1A1CYP2C19AR
Dydrogesterone SCHEMBL23383832 1.00 CYP3A4 (1.00) CYP3A4PGRALDH1A1CYP2C19AR
Dydrogesterone SCHEMBL18814051 1.00 CYP3A4 (1.00) CYP3A4PGRALDH1A1CYP2C19AR
Dydrogesterone SCHEMBL23360787 1.00 CYP3A4 (1.00) CYP3A4PGRALDH1A1CYP2C19AR
Dydrogesterone SCHEMBL20281282 1.00 CYP3A4 (1.00) CYP3A4PGRALDH1A1CYP2C19AR
Dydrogesterone SCHEMBL606817 1.00 CYP3A4 (1.00) CYP3A4PGRALDH1A1CYP2C19AR
Dydrogesterone SCHEMBL11512798 1.00 CYP3A4 (1.00) CYP3A4PGRALDH1A1CYP2C19AR
Dydrogesterone SCHEMBL23360802 0.98 CYP3A4 (0.96) CYP3A4PGRALDH1A1CYP2C19AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11992431-B2 Inserter BAYER OY (FI) 2024-05-28 US claimed
US-20210298942-A1 INSERTER BAYER OY (FI) 2021-09-30 US claimed
US-10561524-B2 Inserter BAYER OY (FI) 2020-02-18 US claimed
US-20170196728-A1 INSERTER BAYER OY (FI) 2017-07-13 US claimed
EP-2305195-A1 Drug delivery compositions for improved stability of steroids Theratech, Inc. (US) 2011-04-06 EP claimed
EP-1976997-B1 PROCESS FOR THE PREPARATION OF 11BETA-HYDR0XY-9BETA,10ALPHA-STEROIDS EMPLOYING AMYCOLATOPSIS MEDITERRANEI CELLS SOLVAY PHARM GMBH (DE) 2009-04-08 EP claimed
EP-1976997-A1 PROCESS FOR THE PREPARATION OF 11BETA-HYDR0XY-9BETA, 10ALPHA -STEROIDS EMPLOYING AMYCOLATOPSIS MEDITERRANEI CELLS Solvay Pharmaceuticals GmbH (DE) 2008-10-08 EP claimed
WO-2007082891-A1 PROCESS FOR THE PREPARATION OF 11BETA-HYDR0XY-9BETA, 10ALPHA -STEROIDS EMPLOYING AMYCOLATOPSIS MEDITERRANEI CELLS SOLVAY PHARMACEUTICALS GMBH (DE) 2007-07-26 WO claimed
US-20040266025-A1 Screening and treatment methods for prevention of preterm delivery CYTYC CORPORATION 2004-12-30 US claimed
US-6024974-A TRANSDERMAL DRUG DELIVERY NOVEN PHARMACEUTICALS, INC. (US) 2000-02-15 US claimed
EP-0876131-A4 1998-12-02 EP claimed
EP-0876131-A1 DRUG DELIVERY COMPOSITIONS FOR IMPROVED STABILITY OF STEROIDS THERATECH, INC. (a Delaware Corporation) (US) 1998-11-11 EP claimed
WO-1997003629-A1 DRUG DELIVERY COMPOSITIONS FOR IMPROVED STABILITY OF STEROIDS THERATECH, INC. (US) 1997-02-06 WO claimed
US-4016270-A Method for treating dysmenorrhea with a uterine therapeutic system ALZA CORPORATION (US) 1977-04-05 US claimed
US-4014988-A Method for treating hypermenorrhea with uterine therapeutic system ALZA CORPORATION (US) 1977-03-29 US claimed
US-11992431-B2 Inserter BAYER OY (FI) 2024-05-28 US disclosed
CN-107531746-B8 Preparation method of 9 beta, 10 alpha-pregna-4,6-diene-3,20-dione 台州市海盛制药有限公司 2023-11-10 CN disclosed
US-3993057-A Intrauterine device that bioerodes in response to the environment of the uterus and method of using ALZA CORPORATION (US) 1976-11-23 US disclosed
US-3977404-A OSMOTIC DEVICE HAVING MICROPOROUS RESERVOIR ALZA CORPORATION (US) 1976-08-31 US disclosed
US-3971367-A Intrauterine device having means for changing from uterine-retentive shape to nonuterine-retentive shape ALZA CORPORATION (US) 1976-07-27 US disclosed