Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dydrogesterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | AR | P10275 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.63 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dydrogesterone SCHEMBL29335245 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL606816 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL13907084 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL37703 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL23383832 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL18814051 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL23360787 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL20281282 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL11512798 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRALDH1A1CYP2C19AR | |
| Dydrogesterone SCHEMBL23360802 | 0.98 | CYP3A4 (0.96) | CYP3A4PGRALDH1A1CYP2C19AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119409752-A | Synthesis process of dydrogesterone | 山东驰奥新材料科技有限公司 | 2025-02-11 | — | — | CN | claimed |
| CN-118858479-A | Kit for simultaneously detecting 90 steroid hormones and metabolites thereof in urine sample, detection method and sample pretreatment method | 中国疾病预防控制中心环境与健康相关产品安全所 | 2024-10-29 | — | — | CN | claimed |
| CN-118271381-A | New process for preparing prednisone and other series corticosteroids from progesterone | 天津药业研究院股份有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-118271382-A | New process for preparing series corticosteroids such as prednisolone by using progesterone | 天津药业研究院股份有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-117946198-A | Method for preparing dydrogesterone key intermediate by deep ultraviolet microfluidic technology | 上海善施科技有限公司 | 2024-04-30 | — | — | CN | claimed |
| CN-117030904-B | Method for measuring 144 steroid hormones in environmental sample by liquid chromatography-mass spectrometry | 北京林业大学 | 2023-12-19 | — | — | CN | claimed |
| CN-117030904-A | Method for measuring 144 steroid hormones in environmental sample by liquid chromatography-mass spectrometry | 北京林业大学 | 2023-11-10 | — | — | CN | claimed |
| CN-116813682-A | Synthesis method of 9 alpha, 10 beta-pregna-4, 6-diene-3, 20-dione | 北京济美堂医药研究有限公司 | 2023-09-29 | — | — | CN | claimed |
| CN-116322339-A | Extract containing oleandrin and its preparation method | 菲尼克斯生物技术公司 | 2023-06-23 | — | — | CN | claimed |
| CN-110878112-B | Gas separation flow system and method for photochemical synthesis of 9-beta, 10-alpha-dehydroprogesterone ketal | 山东清创化工有限公司 | 2022-12-27 | — | — | CN | claimed |
| US-6024974-A | TRANSDERMAL DRUG DELIVERY | NOVEN PHARMACEUTICALS, INC. (US) | 2000-02-15 | — | — | US | claimed |
| EP-0876131-A4 | — | — | 1998-12-02 | — | — | EP | claimed |
| EP-0876131-A1 | DRUG DELIVERY COMPOSITIONS FOR IMPROVED STABILITY OF STEROIDS | THERATECH, INC. (a Delaware Corporation) (US) | 1998-11-11 | — | — | EP | claimed |
| US-5780050-A | STORAGE-STABLE PATCH FOR TRANSDERMAL DELIVERY OF 3-KETO-4-EN-CONTAINING STEROID USING A BIOCOMPATABLE ADHESIVE COMPRISING A BLOCK POLYMER OF HYDROXYETHYL ACRYLATE AND N-VINYL-2-PYRROLIDONE; ACID-FREE | THERATECH, INC. (US) | 1998-07-14 | — | — | US | claimed |
| WO-1997003629-A1 | DRUG DELIVERY COMPOSITIONS FOR IMPROVED STABILITY OF STEROIDS | THERATECH, INC. (US) | 1997-02-06 | — | — | WO | claimed |
| US-4230702-A | Readily enterally absorbable pharmaceutical compositions of per se poorly enterally absorbable pharmacologically active agents | KALI-CHEMIE PHARMA GMBH (DE) | 1980-10-28 | — | — | US | claimed |
| US-4177269-A | ANTITUMOR AGENTS | AKTIEBOLAGET LEO (SE) | 1979-12-04 | — | — | US | claimed |
| US-4054651-A | Method of contraception | RICHARDSON-MERRELL INC. (US) | 1977-10-18 | — | — | US | claimed |
| US-4014987-A | VAGINAL DEVICE; USING A HYDROPHOBIC POLYCARBOXYLIC ACID AS DRUG RELEASE RATE CONTROLLER | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| US-4014988-A | Method for treating hypermenorrhea with uterine therapeutic system | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |