Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | PDE1A | P54750 | 2/20 | 0.63 |
| ▸ | PDE2A | O00408 | 1/20 | 0.63 |
| ▸ | PDE9A | O76083 | 1/20 | 0.63 |
| ▸ | PDE4A | P27815 | 1/20 | 0.63 |
| ▸ | PDE6C | P51160 | 1/20 | 0.63 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.63 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29602240 | 0.94 | PDE5A (0.74) | PDE5APDE3BPDE3AKDM4EPDE1A | |
| SCHEMBL23361343 | 0.94 | PDE5A (0.74) | PDE5APDE3BPDE3AKDM4EPDE1A | |
| SCHEMBL29601635 | 0.90 | PDE5A (0.76) | PDE5APDE3BPDE3AKDM4EPDE1A | |
| SCHEMBL23361310 | 0.90 | PDE5A (0.76) | PDE5APDE3BPDE3AKDM4EPDE1A | |
| SCHEMBL23370692 | 0.89 | PDE5A (0.77) | PDE5APDE3BPDE3AKDM4EPDE1A | |
| SCHEMBL28890828 | 0.85 | KDM4E (0.73) | PDE5APDE3BPDE3AKDM4EPDE1A | |
| SCHEMBL23370716 | 0.84 | KDM4E (0.69) | PDE5APDE3BPDE3AKDM4EPDE1A | |
| SCHEMBL29601997 | 0.83 | KDM4E (0.78) | PDE5APDE3BPDE3AKDM4EPDE1A | |
| SCHEMBL23362150 | 0.83 | KDM4E (0.78) | PDE5APDE3BPDE3AKDM4EPDE1A | |
| SCHEMBL23370767 | 0.83 | KDM4E (0.67) | PDE5APDE3BPDE3AKDM4EPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058457-A2 | NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS | Ildong Pharmaceutical Co., Ltd. (KR) | 2022-09-21 | — | — | EP | disclosed |
| CN-115038704-A | Nitrogen oxide donating PDE-5 and/or PDE-6 inhibitor compounds | 日东制药股份有限公司 | 2022-09-09 | — | — | CN | disclosed |
| WO-2021094830-A2 | NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2021-05-20 | — | — | WO | disclosed |