Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25259828 | 0.89 | KDM4E (0.50) | KDM4EPOLBALDH1A1HSD17B10GAA | |
| SCHEMBL31460065 | 0.87 | SOS1 (0.48) | KDM4EPOLBALDH1A1HSD17B10GAA | |
| SCHEMBL7378524 | 0.85 | KDM4E (0.73) | KDM4EPOLBALDH1A1HSD17B10GAA | |
| SCHEMBL14666358 | 0.85 | CFTR (0.53) | KDM4EPOLBALDH1A1HSD17B10GAA | |
| SCHEMBL238197 | 0.82 | LCK (0.66) | KDM4EALDH1A1HSD17B10HTTKMT2A | |
| SCHEMBL12082046 | 0.81 | SMPD1 (0.53) | KDM4EALDH1A1HSD17B10KMT2AMAPK1 | |
| SCHEMBL7466908 | 0.81 | KDM4E (0.68) | KDM4EPOLBALDH1A1HSD17B10GAA | |
| SCHEMBL6582728 | 0.81 | KDM4E (0.67) | KDM4EPOLBALDH1A1HSD17B10GAA | |
| SCHEMBL12497066 | 0.80 | LCK (0.69) | KDM4EPOLBALDH1A1HSD17B10GAA | |
| SCHEMBL29945757 | 0.80 | LCK (0.69) | KDM4EPOLBALDH1A1HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117865925-A | 3, 4-benzocoumarin compound based on complex functional aromatic hydrocarbon and preparation method and application thereof | 上海瑞苷生物科技有限公司 | 2024-04-12 | — | — | CN | disclosed |
| US-20230019280-A1 | SUBSTITUTED ISOINDOLONYL 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2023-01-19 | — | — | US | disclosed |
| WO-2021097075-A1 | SUBSTITUTED ISOINDOLONYL 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230019280-A1 | SUBSTITUTED ISOINDOLONYL 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | HAVCR2, CDV3, HCCS | KDM4E 1888/4885POLB 532/4885ALDH1A1 3200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.