Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 12/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344152 | 0.83 | PHGDH (0.53) | PHGDHHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL19343635 | 0.82 | PHGDH (0.55) | PHGDHHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL19344109 | 0.80 | PHGDH (0.53) | PHGDHHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL25538844 | 0.80 | PHGDH (0.57) | PHGDHHSD17B10THRBRXFP1MAPT | |
| SCHEMBL19342030 | 0.79 | PHGDH (0.47) | PHGDHHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL19347345 | 0.78 | PHGDH (0.51) | PHGDHHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL26326346 | 0.78 | PHGDH (0.51) | PHGDHHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL23366395 | 0.78 | PHGDH (0.51) | PHGDHHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL23366358 | 0.78 | PHGDH (0.48) | PHGDHHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL20793451 | 0.77 | PHGDH (0.53) | PHGDHHPGDALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3884939-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2023-10-25 | — | — | EP | disclosed |
| EP-3426243-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2021-05-19 | — | — | EP | disclosed |