Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | BCHE | P06276 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25334051 | 0.98 | ACHE (0.67) | ACHEKDM4EKMT2ABCHELMNA | |
| Hydrochloric Acid SCHEMBL25330408 | 0.97 | ACHE (0.65) | ACHEKDM4EKMT2ABCHELMNA | |
| Bromide SCHEMBL1069897 | 0.81 | ACHE (0.79) | ACHEKDM4EKMT2ABCHERAB9A | |
| Bromide SCHEMBL2566518 | 0.81 | ACHE (0.61) | ACHEKDM4EKMT2ABCHELMNA | |
| Bromide SCHEMBL2340311 | 0.81 | ACHE (0.97) | ACHEKDM4EKMT2ABCHELMNA | |
| SCHEMBL29729955 | 0.79 | ACHE (0.76) | ACHEKDM4EKMT2ABCHERAB9A | |
| SCHEMBL1127587 | 0.79 | ACHE (0.76) | ACHEKDM4EKMT2ABCHERAB9A | |
| SCHEMBL25356547 | 0.79 | ACHE (0.62) | ACHEKDM4EKMT2ABCHELMNA | |
| Hydrochloric Acid SCHEMBL1071121 | 0.78 | ACHE (0.73) | ACHEKDM4EKMT2ABCHERAB9A | |
| Hydrochloric Acid SCHEMBL29943765 | 0.78 | ACHE (0.73) | ACHEKDM4EKMT2ABCHERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569502-B2 | Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids | Geddes, Chris (US) | 2013-10-29 | — | — | US | disclosed |
| US-20130210158-A1 | QUATERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS | GEDDES, CHRIS, DR. | 2013-08-15 | — | — | US | disclosed |
| US-8338602-B2 | Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2012-12-25 | — | — | US | disclosed |
| EP-1671118-B1 | CYANIDE SENSING COMPOUNDS AND USES THEREOF | UNIV MARYLAND (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-1644330-B1 | QUATERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS | UNIV MARYLAND (US) | 2011-08-17 | — | — | EP | disclosed |
| US-20100297016-A1 | QUARTERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS | GEDDES, CHRIS, DR. | 2010-11-25 | — | — | US | disclosed |
| US-7732215-B2 | Cyanide sensing compounds and uses thereof | UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE (US) | 2010-06-08 | — | — | US | disclosed |
| US-7718804-B2 | Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids | UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE (US) | 2010-05-18 | — | — | US | disclosed |
| EP-1644330-A4 | QUATERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS | UNIV MARYLAND BIOTECH INST (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20080096281-A1 | Cyanide Sensing Compounds and Uses Thereof | GEDDES, CHRIS, DR. | 2008-04-24 | — | — | US | disclosed |
| US-20070020182-A1 | Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids | GEDDES, CHRIS, DR. | 2007-01-25 | — | — | US | disclosed |
| EP-1671118-A2 | CYANIDE SENSING COMPOUNDS AND USES THEREOF | University of Maryland Biotechnology Institute (US) | 2006-06-21 | — | — | EP | disclosed |
| EP-1644330-A2 | QUATERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS | UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005029033-A2 | CYANIDE SENSING COMPOUNDS AND USES THEREOF | UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE (US) | 2005-03-31 | — | — | WO | disclosed |
| WO-2005000109-A2 | QUATERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS | UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297016-A1 | QUARTERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS | SLC5A1, NISCH, SLC5A2 | ACHE 1414/4885KDM4E 4323/4885KMT2A 4551/4885 |
| US-20130210158-A1 | QUATERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS | SLC5A1, NISCH, SLC5A2 | ACHE 1048/4885KDM4E 4482/4885KMT2A 4298/4885 |
| US-20070020182-A1 | Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids | SLC5A1, NISCH, SLC5A2 | ACHE 1048/4885KDM4E 4482/4885KMT2A 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.