Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24160862 | 0.76 | HRH4 (0.49) | HRH4HRH3TAAR1DRD1LMNA | |
| SCHEMBL20144183 | 0.73 | HRH4 (0.47) | HRH4HRH3TAAR1DRD1LMNA | |
| SCHEMBL23584717 | 0.73 | HRH4 (0.47) | HRH4HRH3TAAR1DRD1LMNA | |
| SCHEMBL22990591 | 0.71 | HRH4 (0.61) | HRH4HRH3TAAR1DRD1LMNA | |
| SCHEMBL19343932 | 0.70 | HRH4 (0.54) | HRH4HRH3TAAR1DRD1LMNA | |
| SCHEMBL23369219 | 0.69 | HRH4 (0.48) | HRH4HRH3LMNA | |
| SCHEMBL20231377 | 0.68 | HRH4 (0.56) | HRH4HRH3TAAR1DRD1LMNA | |
| SCHEMBL20234410 | 0.68 | HRH4 (0.56) | HRH4HRH3TAAR1DRD1LMNA | |
| SCHEMBL10445179 | 0.68 | HRH4 (0.56) | HRH4HRH3TAAR1DRD1LMNA | |
| SCHEMBL25739615 | 0.68 | SLC6A2 (0.59) | HRH4HRH3TAAR1DRD1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351552-B1 | 2'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES INC (US) | 2021-05-19 | — | — | EP | disclosed |